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MODERN RHEUMATOLOGY Vol.13 No.4
>MR13-4
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| Successful treatment of pure red cell aplasia and autoimmune cytopenia with cyclosporine and prednisolone in a patient with SjOgrens syndrome |
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| Motoaki Shiratsuchi1 , Yosuke Kitamura1, Youko Suehiro1, Susumu Taniguchi1, Yoshiyuki Sakai1, Takashi Sugimura1, Takayoshi Fukutomi1, Yasuji Yoshikawa2, Satoshi Shiokawa1, Shoichiro Ikuyama1 and Junji Nishimura1 |
(1) Department of Rheumatology and Medicine, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu, 874-0838, Japan
(2) Department of Pathology, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan |
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| Received: 14 December 2002 Accepted: 17 March 2003 |
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| Abstract |
| A 68-year-old woman was admitted to our hospital with xerophthalmia, xerostomia, leukopenia, and thrombocytopenia. She was diagnosed to have SjOgrens syndrome and autoimmune cytopenia. After 11 months, she was readmitted with severe anemia and reticulocytopenia. Mild hemolysis was seen, and bone marrow aspirate showed markedly decreased erythropoiesis. An association of pure red cell aplasia (PRCA) and autoimmune hemolytic anemia was diagnosed. After treatment with cyclosporine and prednisolone, her anemia dramatically improved. We discuss the mechanism of PRCA associated with SjOgrens syndrome. |
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| Key words |
| Autoimmune hemolytic anemia (AIHA) - Leukopenia - Pure red cell aplasia (PRCA) - SjOgrens syndrome (SS) - Thrombocytopenia |
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