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MODERN RHEUMATOLOGY Vol.13 No.3
>MR13-3
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Efficacy of combination treatment with cyclosporin A and corticosteroids for acute interstitial pneumonitis associated with dermatomyositis
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| Kenji Nagasaka1, Masayoshi Harigai2, Mutsuto Tateishi2, Masako Hara2, Yasuyuki Yoshizawa3, Takao Koike4 and Nobuyuki Miyasaka1 |
(1) Department of Bioregulatory Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan
(2) Institute of Rheumatology, Tokyo Women''s Medical University, Tokyo, Japan
(3) Department of Geriatric and Pulmonary Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
(4) Department of Medicine II, Hokkaido University School of Medicine, Sapporo, Japan |
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| Received: 07 November 2002 Accepted: 16 December 2002 |
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| Abstract |
| Interstitial pneumonitis (IP) associated with polymyositis and dermatomyositis (PM/DM) is a serious complication that affects prognosis. We therefore undertook a retrospective multicenter study to examine the efficacy of a combination treatment with cyclosporin A (CsA) and corticosteroids. Fifty-three IP patients with PM/DM (9 PM, 44 DM) were analyzed. Thirty-two patients treated with CsA plus corticosteroids (9 PM, 23 DM) were included in the study. Four parameters, i.e., subjective symptoms, ausculatory sound, chest radiographs, and respiratory index, were serially evaluated. A general evaluation was performed 4 weeks after the start of the combination treatment. All patients with PM and chronic IP with DM, and 52% of those with acute IP with DM were graded as better than partially effective in the general evaluation. In contrast, all patients graded as progressive in the general evaluation had acute IP with DM. It is of note that in acute IP with DM, the survival rate of the group primarily treated with CsA and corticosteroids from the early stage of their disease was significantly higher than that of the group initially treated with corticosteroids alone (P = 0.049). In conclusion, a combination treatment of CsA and corticosteroids from the early stage of disease may be advantageous for patients with IP with PM/DM, especially acute IP with DM. |
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| Key words |
| Cyclosporin A (CsA) - Dermatomyositis (DM) - Interstitial pneumonitis (IP) - Polymyositis (PM) |
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