Behcet's disease accompanied by myelodysplastic syndrome with trisomy 8: two case reports and a review of 15 Japanese cases
Y.Adachi1, A. Tsutsumi1, H. Murata1, H. Takemura1, Y. Chino1, R. Takahashi1, T. Ebitsuka1, T. Sumida1
(1)Division of Rheumatology, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan
Abstract We describe two cases of Behcet's disease associated with myelodysplastic syndrome (MDS) with trisomy 8. Both cases developed ulceration in the cecum as a gastrointestinal complication of Behcet's disease, after a diagnosis of MDS. We summarized recent case reports of Behcet's disease associated with myelodysplastic syndrome, and studied the clinical manifestations. Most cases showed trisomy 8 as a chromosomal abnormality. Gastrointestinal involvement without eye lesions seems to be characteristic of Behcet's disease associated with MDS.
