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MODERN RHEUMATOLOGY Vol.12 No.4
>MR12-4
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| Subclinical renal tubular acidosis in patients with primary and secondary Sjogren's syndrome: a possible marker of disease progression |
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| S. Nishinarita1, S. Kinoshita1, M. Kaneko1, T. Shimizu1, K. Son1, M. Aoki1, N. Kitamura1, Y. Matsukawa1, M. Hiranuma2, T. Horie1 |
(1)Department of Internal Medicine, Nihon University School of Medicine, 30 Oyaguchi, Itabashi-ku, Tokyo 173-8610, Japan
(2)Internal Medicine, Municipal Akiru General Hospital, Tokyo, Japan |
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| Abstract |
| Abstract To clarify the prevalence of subclinical renal tubular acidosis (RTA) and its association with clinical and laboratory parameters in primary and secondary Sjogren's syndrome (SS), an acid-loading test was conducted. Subclinical RTA was found in 32% of patients with SS. The prevalence of subclinical RTA in primary and secondary SS was about the same (31.6% and 33.3%, respectively). Significant longer duration of illness, more severely decreased salivary excretion, decreased lymphocyte number, higher serum levels of IgG and IgA, and higher frequency of anti-SS-A (Ro) and SS-B (La) antibodies were found in patients with subclinical RTA. These results suggested that subclinical RTA may be a characteristic manifestation both in primary and secondary SS, along with the progression of immunologic dysfunction, when the illness seemed to be indolent. |
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| Key words |
| Key words Extraglandular involvement ・ Renal tubular acidosis (RTA) ・ Sjogren's syndrome (SS) |
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