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MODERN RHEUMATOLOGY Vol.12 No.3
>MR12-3
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| A male patient who developed late-onset primary biliary cirrhosis presenting with antinuclear envelope antibodies |
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| K. Miyachi1, T. Horigome2, Y. Matsuoka3, S. Irimajiri3, M. Shibata4, K. Asada5, R. W. Hankins6 |
(1)Keigu Clinic, 2-2 Ichibanishinaka-cho, Tsurumi-ku, Yokohama 230-0023, Japan
(2)Department of Biochemistry and Biology, Faculty of Science, Niigata University, Niigata, Japan
(3)Department of Internal Medicine, Kawasaki Municipal Hospital, Kawasaki, Japan
(4)Second Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
(5)Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine, Yokohama, Japan
(6)First Diagnostic Division, Health Sciences Research Institute, Yokohama, Japan |
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Full Text
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| Abstract |
| Abstract An 81-year-old man who had previously shown high levels of alkaline phosphatase (ALP), %-glutamyltransferase (GTP), and total bilirubin presented with acute liver damage. He was positive for serum anti-gp210 and anti-p62 antibodies, but negative for serum antimitochondrial antibody. A liver biopsy revealed massive interstitial fibrosis and pseudolobulus, which were compatible with a diagnosis of primary biliary cirrhosis (PBC) at Scheuer's stage 4. He was given ursodeoxycolic acid at 600 mg/day. However, his condition deteriorated, and he eventually died of hepatic insufficiency in a state of malnutrition. We hypothesize that the presence of anti-gp210 and anti-p62 complex protein antibodies, rather than that of antimitochondrial antibodies, was correlated with the progression of PBC in this particular case. |
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| Key words |
| Key words Anti-gp210 antibody ・ Antinuclear envelope antibody (ANEA) ・ Anti-p62 complex antibody ・ Primary biliary cirrhosis (PBC) ・ Sjogren's syndrome (SS) |
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