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MODERN RHEUMATOLOGY Vol.11 No.3
>MR11-3
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| Guillain-Barre syndrome following herpes zoster in a patient with systemic sclerosis |
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| M. Yamaguchi1, A. Chiba2, T. Yanagawa1, T. Mato1, K. Hirai1, T. Inoue1, Y. Oya2, S. Kusunoki2, K. Ito1, K. Yamamoto1 |
(1)Department of Medicine and Physical Therapy, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
(2)Department of Neurology, University of Tokyo School of Medicine, Tokyo, Japan |
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| Abstract |
| Abstract We report the case of a patient with systemic sclerosis (SSc) who developed Guillain-Barre syndrome (GBS) 6 weeks after herpes zoster. Muscle weakness developed first, and thereafter severely in the muscles in the same segment as the zoster. Serum anti-GM1 and -GD1b IgM autoantibodies were detected in the acute phase. The clinical course and the findings of nerve conduction studies and a sural nerve biopsy were compatible with GBS accompanied by underlying chronic polyneuropathy. SSc might have affected the neurological manifestation via the development of underlying neuropathy and a possible contribution to the autoimmune basis in GBS. |
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| Key words |
| Key words Antiganglioside antibodies ・ Guillain-Barre syndrome ・ Herpes zoster ・ Myelodysplastic syndrome ・ Systemic sclerosis |
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