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MODERN RHEUMATOLOGY Vol.11 No.2
>MR11-2
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| Systemic sclerosis in two second cousins: a case report |
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| T. Kuroda1, S. Murakami2, S. Honda1, Y. Ohfuchi2, S. Hirose1, H. Hasegawa1, A. Murasawa2, M. Nakano1, F. Gejyo1 |
(1)Department of Medicine II, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
(2)Department of Rheumatology, Niigata Prefectural Senami Hospital, Murakami, Niigata, Japan |
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| Abstract |
| Abstract We describe two second cousins who developed systemic sclerosis. These patients had major histocompatibility complex (MHC) class I alleles in common, including A2, A26(10), B60(40), and Cw7 as well as class II allele DR2. This DR2 was thought to be associated with the onset of the disease. Our patients both experienced a limited type of systemic sclerosis, but the expression of autoantibodies was different. |
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| Key words |
| Key words HLA ・ Relatives ・ Systemic sclerosis |
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