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MODERN RHEUMATOLOGY Vol.11 No.1
>MR11-1
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| Predictors of rheumatoid arthritis in patients who have monoarthritis in a knee joint |
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| N. Tanaka1, Y. Yamada2, H. Sakahashi1, E. Sato1, S. Ishii2 |
(1)Rheumatology Unit, Gorinbashi Orthopedic Hospital in Gorinbashi Health Care Facilities and Hospitals, 2-1 Kawazoe, Minami-ku, Sapporo 005-0802, Japan
(2) Department of Orthopedic Surgery, School of Medicine, Sapporo Medical University, Sapporo, Japan |
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| Abstract |
| Abstract To determine the predictive factors for rheumatoid arthritis (RA), 79 patients (11 men, 68 women; average age at onset of symptoms 37.1 years) with fixed joint effusion of one knee joint, of minimum 6 months' duration, were divided into three groups: group I, 11 patients (14%) who progressed to RA; group II, 8 patients (10%) with the correct diagnosis, except that RA became apparent during the subsequent follow-up; group III, 60 patients (76%) whose joint effusion resolved. In group I, the degree of joint effusion and the serological values of interleukin (IL)-1#, IgG-RF, and rheumatoid factor (RF) tended to be higher than those in the other groups at the time of our initial examination. The synovial fluid concentrations of IL-1# and IgG-RF in group I were significantly higher than those in the other groups. Magnetic resonance imaging (MRI)-determined stage and histological assessment of synovial inflammation also tended to be higher in group I than in the other groups. This study revealed that it might be possible to predict the outcome of cases of monoarthritis by examining IL-1# and IgG-RF levels in the synovial fluid, in addition to various elevated inflammation signs in the knee joint. |
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| Key words |
| Key words Interleukin-1 ・ Rheumatoid factor ・ Rheumatoid monoarthritis ・ Synovial fluid |
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