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MODERN RHEUMATOLOGY Vol.11 No.1
>MR11-1
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| Expression of membrane-type matrix metalloproteinases in synovial tissue from patients with rheumatoid arthritis or osteoarthritis |
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| H. Mitsui 1, N. Tsuchiya2, S. Okinaga3, K. Matsuta4, K. Yoshimura5, A. Nishimura5 |
(1)Department of Orthopedics, Mitsui Memorial Hospital, Tokyo, Japan
(2)Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
(3)Department of Orthopedics, Kanto Central Hospital, Tokyo, Japan
(4)Matsuta Clinic, Tokyo, Japan
(5)Discovery Research Laboratories II, Pharmaceutical Discovery Research Division, Takeda Chemical Industries Ltd., 10 Wadai, Tsukuba 300-4247, Japan |
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| Abstract |
| Abstract We investigated the expression of membrane-type matrix metalloproteinase (MT-MMP) and matrix metalloproteinase (MMP) mRNAs in synovial tissue from patients with rheumatoid arthritis (RA, n = 5) or osteoarthritis (OA, n = 5) by Northern blot analysis. Northern analysis demonstrated strong expression of MT1-MMP, MT3-MMP, MMP-1, and MMP-3 and weak expression of MT2-MMP and MMP-8 in synovial tissue from patients with RA or OA. MT4-MMP was not detected. No significant difference was shown in the expression of MT-MMP mRNAs between RA and OA. Synovial tissue of RA or OA patients expressed MT-MMPs as well as MMPs. These results indicate that, in addition to MMPs, MT1-MMP, MT3-MMP, and probably MT2-MMP may play a role in the degradation of bone and cartilage matrix in RA and OA. Such information may provide a clue to the development of a novel therapeutic approach targeted on the prevention of joint destruction. |
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| Key words |
| Key words Matrix metalloproteinases (MMPs) ・ Membrane-type matrix metalloproteinases (MT-MMPs) ・ Osteoarthritis (OA) ・ Rheumatoid arthritis (RA) ・ Synovial tissues |
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