The development of Th1-mediated sarcoidosis improves the clinical course of Th2-mediated atopic dermatitis

Vol.21 No.4

Case Report

The development of Th1-mediated sarcoidosis improves the clinical course of Th2-mediated atopic dermatitis

Authors

Tomomitsu Miyagaki¹ , Yoshihide Asano¹ , Sayaka Shibata¹ , Yuki Ohno¹ , Yuichiro Tsunemi¹ , Hidehisa Saeki¹ , Kunihiko Tamaki¹ , Shinichi Sato¹

Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

Received:

12 October 2010

Accepted:

3 December 2010

Published online:

13 January 2011

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Abstract

Sarcoidosis is a chronic multisystem disease of unknown origin, which is characterized by T-helper-1 (Th1)-mediated immune responses. On the other hand, atopic dermatitis (AD) is characterized by Th2-mediated immune responses. We recently experienced an interesting case of AD in which the patient experienced a significant resolution of AD after the onset of sarcoidosis. We herein describe the details of his clinical course and discuss the impact of negative cross-regulation between Th1 and Th2 immune responses.

Key words

Atopic dermatitis - Sarcoidosis - Th1/Th2 balance