Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men
Tomoko Yokoyama1 , Takashi Usui1,2 , Kazuhiro Kiyama1 , Ran Nakashima1 , Naoichiro Yukawa1 , Daisuke Kawabata1 , Takaki Nojima1 , Koichiro Ohmura1 , Takao Fujii1 , Tsuneyo Mimori1
7 January 2010
16 February 2010
8 April 2010
PDF (member's only)
We have experienced two cases of drug-induced lupus erythematosus caused by ticlopidine in the last three years. Both were late-onset cases (1 and 4 years) that occurred in elderly men (76 and 81 years old). The common features were fever, arthralgia, myalgia, serositis, and the presence of anti-histone autoantibodies. Because ticlopidine is widely used in elderly people with ischemic vascular disease, ticlopidine-induced lupus should be considered when patients taking ticlopidine present lupus-like symptoms.
Drug-induced lupus erythematosus - Ticlopidine - Anti-histone antibody