Resolution of anti-neutrophil cytoplasmic antibody-associated vasculitis after resection of gastric cancer

Vol.20 No.1

Case Report

Resolution of anti-neutrophil cytoplasmic antibody-associated vasculitis after resection of gastric cancer

Authors

Yoshinori Hosoya¹ , Seiji Minota² , Alan Lefor¹ , Kazuya Sakuma¹ , Yoko Aoki² , Takeshi Kamimura² , Yasunori Niwa³ , Eiji Kajii³ , Nobuyuki Kanai⁴ , Yoshikazu Yasuda¹

Department of Surgery, Jichi Medical University, 3311-1 Shimotsuke, Tochigi 329-0498, Japan
Department of Rheumatology and Clinical Immunology, Jichi Medical University, Tochigi, Japan
Department of Community and Family Medicine, Centre for Community Medicine, Jichi Medical University, Tochigi, Japan
Department of Pathology, Jichi Medical University, Tochigi, Japan

Received:

25 May 2009

Accepted:

8 September 2009

Published online:

3 October 2009

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Abstract

We report a case of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis in a 62-year-old patient with gastric cancer. The myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) level was threefold above normal preoperatively. Vasculitis was seen on renal biopsy. Gastric resection revealed well-differentiated adenocarcinoma and vasculitis. The MPO-ANCA level returned to normal post-operatively. Although ANCA-associated vasculitis occasionally accompanies malignant tumors, this is the first documented case of concurrent gastric cancer-associated and ANCA-associated vasculitis, with post-operative resolution of the vasculitis.

Key words

ANCA-associated vasculitis - Gastric cancer - Myeloperoxidase-anti-neutrophil cytoplasmic antibody