Vol.19 No.6

Case Report

Rheumatoid arthritis associated with osteopetrosis

Authors

Yuho Kadono1 , Sakae Tanaka1 , Jinju Nishino2 , Keita Nishimura2 , Ichiro Nakamura3 , Tsuyoshi Miyazaki4 , Hiroshi Takayanagi5 , Kozo Nakamura1

  • Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
  • Department of Orthopaedic Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan
  • Department of Rheumatology, Yugawara Kosei-nenkin Hospital, 438 Miyakami, Yugawara, Ashigara-shimo Kanagawa, 259-0314, Japan
  • Department of Geriatric Medicine, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
  • Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
Received:

2 April 2009

Accepted:

7 July 2009

Published online:

6 August 2009

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Abstract

Osteopetrosis is an inherited disorder characterized by reduced bone resorption. We here report a rare case of osteopetrosis associated with rheumatoid arthritis. The patient was diagnosed as autosomal dominant osteopetrosis type II in his youth and developed rheumatoid arthritis at 42 years of age. In spite of the severe inflammation and rapid progression of cartilage destruction, the progression of bone erosion was slow in this patient.

Key words

Bone erosion - Osteoclast - Osteopetrosis - Rheumatoid arthritis