Radiographic repair in three Japanese patients with rheumatoid arthritis treated with bucillamine

Vol.19 No.6

Case Report

Radiographic repair in three Japanese patients with rheumatoid arthritis treated with bucillamine

Authors

Yuki Nanke¹ , Masako Iwatani¹ , Tsuyoshi Kobashigawa¹ , Toru Yago¹ , Hisashi Yamanaka¹ , Shigeru Kotake¹

Institute of Rheumatology, Tokyo Women’s Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan

Received:

3 February 2009

Accepted:

7 July 2009

Published online:

27 August 2009

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Abstract

Bucillamine (Bc) is a cysteine derivative with two SH groups, and a homolog of d-penicillamine, a disease-modifying antirheumatic drug (DMARD) widely used in Japan. However, it remains unclear whether Bc repairs bone erosion in patients with RA. Here, we treated three RA patients with Bc who subsequently showed radiographic repair of erosions and cysts.

Key words

Rheumatoid arthritis - Bucillamine - Antirheumatic agents - Bone destruction - Erosion