Vol.19 No.6

Review Article

The specificity of capillaroscopic pattern in connective autoimmune diseases. A comparison with microvascular changes in diseases of social importance: arterial hypertension and diabetes mellitus

Authors

Sevdalina Nikolova Lambova1 , Ulf Müller-Ladner2

  • Clinic of Rheumatology, Medical University, 15A “Vasil Aprilov” Blvd, 4002 Plovdiv, Bulgaria
  • Department for Internal Medicine and Rheumatology, Justus-Liebig University Giessen, Department for Rheumatology and Clinical Immunology, Kerckhoff Clinic, Bad Nauheim, Germany
Received:

24 February 2009

Accepted:

29 July 2009

Published online:

25 September 2009

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Abstract

Capillaroscopy is a method with substantial value for diagnosis and differentiation of primary and secondary Raynaud’s phenomenon in rheumatic diseases. The most specific finding is in systemic sclerosis-the so-called “scleroderma pattern.” which is characterized by the presence of dilated capillaries, hemorrhages, avascular areas, and neoangiogenesis. Similar changes are found in patients with dermatomyositis, overlap syndromes, and others and are termed “scleroderma-like pattern.” For the development of these patterns, the most specific finding in the early phase is appearance of dilated capillaries. Capillaroscopic changes in connective autoimmune diseases are specific and differ significantly from those of that can be found in other diseases. Diseases of social importance such as diabetes mellitus and arterial hypertension often present as comorbidity in patients with rheumatic diseases. In diabetes mellitus, the capillaroscopic examination does not show dilated capillaries until the advanced stages of the disease. In the late stages of connective tissue disease, a loss of capillaries is typical. In addition, in diabetes mellitus, the diabetic stiff-hand syndrome and sclerodactyly are common complications, which have to be differentiated from similar signs in rheumatic diseases, and capillaroscopic examination appears to be useful in these situations. In arterial hypertension, a reduced capillary density in different body regions has been observed in patients with established disease as well as in preclinical stages. Analogous phenomenon of reduction in the nail-fold area has also been observed in a group of patients with essential hypertension, none of whom previously received hypertensive drugs.

Key words

Capillaroscopy - Connective autoimmune diseases - Arterial hypertension - Diabetes mellitus