Vol.19 No.1

Case Report

Clinical utility of computed tomographic scanning for the evaluation of lupus profundus in two patients with systemic lupus erythematosus

Authors

Takashi Kato1,2 , Ayako Nakajima1 , Tokiko Kanno1 , Mikiko Shinozaki1 , Takahisa Gono1 , Hisae Ichida1 , Ikuko Masuda1 , Naoyuki Kamatani1 , Masako Hara1

  • Institute of Rheumatology, Aoyama Hospital, Tokyo Women’s Medical University, 2-7-13 Kitaaoyama, Minato-ku, Tokyo 107-0061, Japan
  • Institute of Rheumatology, Tokyo Women’s Medical University, 10-20 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan
Received:

7 May 2008

Accepted:

1 September 2008

Published online:

7 October 2008

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Abstract

Lupus profundus is a rare lupus-specific skin lesion with skin biopsies exhibiting lobular lymphocytic infiltration and destruction of subcutaneous fat tissue. In this report, a CT scan was effective in demonstrating both the presence and the extent of inflammation of lupus profundus in two patients with systemic lupus erythematosus (SLE). Case 1 was a 30-year-old woman developing erythema with subcutaneous induration on the upper arms during the quiescent phase of SLE. A skin biopsy confirmed a diagnosis of lupus profundus. A CT scan of the right upper arm demonstrated a high density area (HDA) of the subcutis under the erythema: a finding consistent with lupus profundus. Case 2 was a 28-year-old woman recently diagnosed with SLE. She also developed a skin ulcer on the right hip. A CT scan of the hip revealed an HDA and lipoatrophy of the subcutis around the ulcer: these findings were compatible with lupus profundus. Treatment with high-dose prednisolone improved the illness in the both cases. A CT scan is a useful and convenient imaging modality for confirming the diagnosis of lupus profundus.

Key words

Biopsy - Computed tomographic (CT) scan - Diagnosis - Lupus profundus - Panniculitis - Systemic lupus erythematosus