Vol.18 No.6

Original Article

Decrease in CD4⁺CD25⁺ and CD8⁺CD28⁺ T cells in interstitial pneumonitis associated with rheumatic disease

Authors

Akira Katagiri¹ , Shinji Morimoto¹ , Yutaka Nakiri¹ , Souichiro Nakano¹ , Akiko Mitsuo¹ , Jun Suzuki¹ , Hirofumi Amano¹ , Kazuhisa Nozawa¹ , Masanao Asano¹ , Yoshiaki Tokano¹ , Hiroshi Hashimoto¹ , Yoshinari Takasaki¹

Received:

7 February 2008

Accepted:

7 May 2008

Published online:

19 June 2008

Full Text

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Abstract

The expression of CD25 or CD28 on T cells was examined in patients with rheumatic diseases associated with interstitial pneumonitis (IP), in order to investigate the conditions of CD4⁺CD25⁺ regulatory T cells and CD8⁺CD28^- suppressor T cells. Fifty-five patients with various rheumatic diseases and 23 normal controls were enrolled. CD4⁺CD25⁺ T cells of patients with IP were significantly decreased in comparison with non-IP patients, and the ratio of CD8⁺CD28^- T cells in patients with IP was significantly higher than that in non-IP patients or normal controls. These results for CD8⁺CD28^- T cells were in accord with the decrease in CD8⁺CD28⁺ T cells, and may be related to activation-induced CD8⁺CD28⁺ T-cell death. Thus, the abnormality of CD4⁺CD25⁺ regulatory T cells may be related to the pathogenesis of IP, and the survival and activation of CD8⁺ T cells.

Key words

CD4⁺CD25⁺ regulatory T cell
- CD8⁺CD28^- suppressor T cell
- Interstitial pneumonitis
- Rheumatic diseases
- CD62L