Successful treatment with plasma exchange in adult-onset Still’s disease with hyper-IL-18-naemia and hyperallergic state
Tomoki Ito1 , Yoshio Ozaki1 , Keiko Shimamoto1 , Hideki Amuro1 , Tsutomu Tanijiri1 , Takashi Yokoi1 , Yonsu Son1 , Kenichirou Tajima1 , Shirou Fukuhara1
5 September 2007
3 March 2008
29 April 2008
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Adult-onset Still’s disease (AOSD) is a rheumatoid disorder characterized by high fever, polyarthritis, leukocytosis, hyperferritinaemia, and mild liver involvement. We describe the case of a patient with AOSD with severe liver dysfunction. His serum levels of interleukin-10 and 18 showed a similar trend to his disease activity. Drug lymphocyte stimulation tests were positive for three drugs in the patient. Hypercytokinaemia was controlled by plasma exchange therapy.
Adult-onset Still’s disease - Drug lymphocyte stimulation test - Hepatitis - Interleukin-10