CASE REPORT

A case of mixed connective tissue disease complicated with thymic carcinoma and Hashimoto's thyroiditis

Authors

Yoshito Yoshidome¹, Shigeaki Hayashi¹, Yoshikazu Maruyama¹, Toshi Yoneda², Daisuke Matsuzoe², Takehito Kawakami², Hiroshi Shirahama³, Yukie Tashiro³ and Nobutaka Eiraku⁴

1. Department of Neurology, Imakiire General Hospital, Kagoshima, Japan
2. Department of Chest Surgery, Imakiire General Hospital, Kagoshima, Japan
3. Department of Pathology, Imakiire General Hospital, Kagoshima, Japan
4. Health Service Center, Kagoshima University, Kagoshima, Japan

Received:

31 July 2006

Accepted:

27 September 2006

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Abstract

We report the case of a 63-year-old woman who suffered from mixed connective tissue disease (MCTD) complicated with thymic carcinoma and Hashimoto's thyroiditis. Although many systemic syndromes associated with thymoma and thymic carcinoma, i.e., myasthenia gravis, pure red cell aplasia, hypogammaglobulinemia, and Hashimoto's thyroiditis, are known, this is the first report of MCTD complicated with thymic carcinoma. It was suggested that MCTD may be a paraneoplastic syndrome associated with thymic carcinoma.

Key words

Hashimoto's thyroiditis - Mixed connective tissue disease - Paraneoplastic syndrome - Thymic carcinoma